Interstate 40 runs east and west just north of the Chickasaw Nation. Interstate 35, running north and south, bisects the western part of the Chickasaw Nation. There are many four-lane state highways and two-lane super highways throughout the territory of the Chickasaw Nation, as well as many secondary asphalt, concrete and gravel roads. A traveler can go almost anywhere in the Chickasaw Nation on good, paved roads.

Commercial air travel is available through nearby Dallas, Texas, Oklahoma City and Tulsa. In addition, access to the Gulf of Mexico is provided through the Port of Catoosa, near Tulsa, and down the Arkansas River to the Mississippi River.